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Glucocerebrosidase utilizes the transportprotein lysosomal integral membrane protein 2 (LIMP-2) for delivery to the lyso-some (Fig. A small amount ofbone marrow is obtained by ap-plying negative pressure with a syringe attached to the needle.The aspirate is then spread as a smear on a glass slide and thespecimen is examined with the microscope to examine indi-vidual cell morphology.

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In case of staphylococcal infection, the oralcombination regimen should include rifampin [49], and in PJI caused by Gram-negativebacilli, a fluoroquinolone [51, 52, 52a] is the best choice (see Chapter 8).